Maternal fructose intake modulates cholesterol metabolism in response to a western diet in the offspring

Fructose consumption has increased during the last decades, while a simultaneous rise in incidence of pathologies such as type 2 diabetes and metabolic syndrome also taken place. Although there is evidence that fructose can cause alterations offspring related to development aforementioned diseases, exposure pregnancy not contraindicated for women. This effect explained by concept foetal programming, which suggests changes occur embryogenic stages are permanent adult, due maternal health, diet other environmental factors. Therefore, on cholesterol metabolism mothers fed with or without gestation was studied. In addition, progeny received different diets: (with supplementation cholesterol) tagatose solutions. Tagatose non-HDL water-fed mothers, whereas dampened this effect, indicating programming. feeding atherogenic indices decreasing HDL-cholesterol concentration increasing triglycerides levels. On hand, addition caused an increase total change its distribution: higher lower HDL cholesterol, independently feeding. indices. Ultimately, results indicate influenced both consumption, subsequent intake (alone combination offspring.